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. 2018 Jul 3;9(51):29619–29633. doi: 10.18632/oncotarget.25651

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Copyright: © 2018 Honjo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The aromatase enzyme activities for E2 production were measured in both secreted and non-secreted fractions. (A and B) Secreted fractions of E2 biosynthesis from aromatase activity in SK-BR-3 cells were significantly increased after PCP4/PEP19 overexpression (B: PCP4 plasmid + as open column), but it showed no significance (p=0.1081) in PCP4/PEP19 knockdown (A: PCP4 siRNA + as open column). (C and D) Cytoplasmic fractions of E2 biosynthesis from aromatase activity were also significantly decreased after PCP4/PEP19 knockdown (C: PCP4 siRNA + as open column) and increased after PCP4/PEP19 overexpression (D: PCP4 plasmid + as open column). ^**p<0.01 and ^*** p<0.001 vs without knockdown or overexpression.