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(A) Colon carcinoma cell line HCT116 was treated with the indicated doses (0–500 µM) of IT-139 alone or in the presence of Tg or Tu. GRP78 protein levels detected by Western blot show suppression of GRP78 under Tg and Tu-induced stress conditions. (B) Relative levels of GRP78 were analyzed in hepatocellular carcinoma (HepG2). IT-139 suppressed GRP78 levels under stress conditions. Tg: thapsigargin. Tu: tunicamycin.
