Table 1. Breast cancer subtypes and genomic characteristics of BRCA2-mutated PDX models.
| HBCx22 TamR | HBCx-17 | |
|---|---|---|
| Subtype | Luminal B | Basal-like |
| Germline BRCA2 mutation | c.6405_6409del5, p.Asn2135Lysfs*3 (NM_000059.3) | c.6033_6034del, p.Ser2012GlnFs*5 (NM_000059.3) |
| PIK3R1 | c.1704_1727del, p.Arg569_Thr576del (NM_181523.1) | Wild-type |
| PI3KCA | Wild-type | Wild-type |
| PTEN | c.314G>T, p.Cys105Phe (NM_000314.4) LOH and protein loss |
Intragenic deletion LOH and protein loss |
| Reference | Cottu et al. (2014) | De Plater et al. (2010) |