Figure 6. BG increases TMZ inhibitory effect on breast cancer growth in vivo.

The combination BG+TMZ produced the greatest decrease (80%) in median tumor volume (103.5 mm3) as compared with control mice (460.3 mm³) (p< 0.0001) (Figure 6). Tumor weight was also significantly reduced (80%) in mice treated with BG + TMZ combination therapy (61.9 mg) as compared with control mice (361.3 mg) (p<0.0003) (Table 1). TMZ alone decreased tumor volumes and weights by 45% and BG alone by 65%. Body weight was not changed among all treatment groups as compared with control mice. No visible liver metastases were present (enumerated with the aid of a dissecting microscope) in any of the treatment groups. All slides were reviewed by a board certified pathologist.