Table 4. The influence of APEH genotypes on the severity of oral mucositis after subsequent weeks of radiotherapy.
| RTH week | Radiation reaction grade | CC (n = 23; %) | GG or GC (n = 39; %) | p, OR [95% CI] | GG (n = 12; %) | CC or GC (n = 50; %) | p, OR [95% CI] | CG (n = 27; %) | CC or GG (n = 35; %) | p, OR [95% CI] |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 0 (n = 6; 9.7%) | 4 (66.67%) | 2 (33.33%) | 0.1355 0.26 [0.04–1.53] |
– | 6 (100.0%) | 0.3886 3.65 [0.19–69.36] |
2 (33.33%) | 4 (66.67%) | 0.5981 1.61 [0.27–9.54] |
| 1 (n = 56; 90.3%) | 19 (32.20%) | 37 (67.80%) | 12 (21.43%) | 44 (78.57%) | 25 (44.64%) | 31 (55.36%) | ||||
| 2 | 1 (n = 36; 58.1%) | 16 (44.44%) | 20 (55.56%) | 0.1624 0.46 [0.15–1.37] |
7 (19.44%) | 29 (80.56%) | 0.9832 0.99 [0.27–3.54] |
13 (36.11%) | 23 (63.89%) | 0.1671 2.06 [0.74–5.77] |
| 2 (n = 26; 41.9%) | 7 (26.92%) | 19 (73.08%) | 5 (19.23%) | 21 (80.77%) | 14 (53.85%) | 12 (33.33%) | ||||
| 3 | 1 (n = 21; 33.9%) | 12 (57.14%) | 9 (42.86%) | 0.0222 0.27 [0.09–0.83] |
3 (14.29%) | 18 (185.71%) | 0.4728 1.69 [0.40–7.04] |
6 (28.57%) | 15 (71.43%) | 0.0934 2.08 [0.68–6.36] |
| 2 and 3 (n = 41; 66.1%) | 11 (26.83%) | 30 (73.17%) | 9 (21.95%) | 32 (78.05%) | 21 (51.22%) | 20 (48.78%) | ||||
| 1 and 2 (n = 56; 90.3%) | 22 (39.29%) | 34 (60.71%) | 0.2984 0.31 [0.03–2.83] |
11 (19.64%) | 45 (26.79%) | 0.8610 0.82 [0.09–7.73] |
23 (41.07%) | 33 (58.93%) | 0.1810 2.62 [0.85–8.11] |
|
| 3 (n = 6; 9.7%) | 1 (16.67%) | 5 (83.33%) | 1 (16.67%) | 5 (83.33%) | 4 (66.67%) | 2 (33.33%) | ||||
| 4 | 1 (n = 11; 17.7%) | 8 (72.73%) | 3 (27.27%) | 0.0125 0.16 [0.04–0.67] |
2 (18.18%) | 9 (81.82%) | 0.9136 1.10 [0.20–5.89] |
1 (9.09%) | 10 (90.91%) | 0.0310 10.40 [1.23–87.31] |
| 2 and 3 (n = 51; 82.3%) | 15 (29.41%) | 36 (70.59%) | 10 (19.60%) | 41 (80.40%) | 26 (50.98%) | 25 (49.02%) | ||||
| 1 and 2 (n = 48; 77.4%) | 20 (41.67%) | 28 (58.33%) | 0.1776 0.38 [0.09–1.55] |
7 (14.58%) | 41 (85.42%) | 0.0880 3.25 [0.84–12.62] |
21 (43.75%) | 27 (56.25%) | 0.9527 0.96 [0.29–3.21] |
|
| 3 (n = 14; 22.6%) | 3 (21.43%) | 11 (78.57%) | 5 (35.71%) | 9 (64.29%) | 6 (42.86%) | 8 (57.14%) | ||||
| 5 | 1 (n = 6;9.7%) | 4 (66.67%) | 2 (33.33%) | 0.1355 0.26 [0.04–1.53] |
2 (33.33%) | 4 (66.67%) | 0.3723 0.43 [0.07–2.71] |
– | 6 (100.00%) | 0.0944 12.12 [0.65–225.38] |
| 2 and 3 (n = 56.;90.3%) | 19 (33.93%) | 37 (66.07%) | 10 (17.86%) | 46 (82.14%) | 27 (48.21%) | 29 (51.79%) | ||||
| 1 and 2 (n = 48;77.4%) | 20 (41.67%) | 28 (58.33%) | 0.1776 0.38 [0.09–1.55] |
7 (14.58%) | 41 (85.42%) | 0.0880 3.25 [0.84–12.62] |
21 (43.75%) | 27 (56.25%) | 0.9527 0.96 [0.29–3.21] |
|
| 3 (n = 14; 22.6%) | 3 (21.43%) | 11 (78.57%) | 5 (35.71%) | 9 (64.29%) | 6 (42.86%) | 8 (57.14%) | ||||
| 6 | 1 (n = 6; 9.7%) | 4 (66.67%) | 2 (33.33%) | 0.1355 0.26 [0.04–1.53] |
2 (33.33%) | 4 (66.67%) | 0.3723 0.43 [0.07–2.71] |
– | 6 (100.00%) | 0.0944 12.12 [0.65–225.38] |
| 2 and 3 (n = 56; 90.3%) | 19 (33.93%) | 37 (66.07%) | 10 (17.86%) | 46 (82.14%) | 27 (48.21%) | 29 (51.79%) | ||||
| 1 and 2 (n = 47; 75.8%) | 18 (38.30%) | 29 (61.70%) | 0.7292 0.81 [0.24–2.74] |
10 (21.28%) | 37 (78.72%) | 0.5018 0.57 [0.11–2.95] |
19 (40.43%) | 28 (59.57%) | 0.3824 1.68 [0.52–5.42] |
|
| 3 (n = 15; 24.2%) | 5 (33.33%) | 10 (66.67%) | 2 (13.33%) | 13 (86.67%) | 8 (53.33%) | 7 (46.67%) | ||||
| 7 | 1 (n = 5; 8.1%) | 4 (80.00%) | 1 (20.00%) | 0.0713 0.12 [0.01–1.20] |
1 (20.00%) | 4 (80.00%) | 0.9696 0.96 [0.10–9.43] |
– | 5 (100.00%) | 0.1262 9.92 [0.52–187.73] |
| 2 and 3 (n = 57; 91.9%) | 19 (33.33%) | 38 (66.67%) | 11 (19.30%) | 46 (80.70%) | 27 (47.37%) | 30 (52.63%) | ||||
| 1 and 2 (n = 36; 58.1%) | 18 (50.00%) | 18 (50.00%) | 0.0166 0.23 [0.07–0.77] |
4 (11.11%) | 32 (88.89%) | 0.0619 3.56 [0.94–13.47] |
14 (38.89%) | 22 (61.11%) | 0.3850 1.57 [0.57–4.36] |
|
| 3 (n = 26; 41.9%) | 5 (19.23%) | 21 (80.77%) | 8 (30.77%) | 18 (69.23%) | 13 (50.00%) | 13 (50.00%) |