PC12 cells were incubated under OGD for 2 h, and they were then separately incubated with the following reagents for 3 h: MFQ (5 μM), KN-93 (2 μM), and leonurine (50, 100, and 200 μg/mL). Then the cells were cultured under normal conditions for 24 h. Cell viability was assessed using cell counting kit-8. CON, normal control group; OGD, OGD-for-control group; LOW+OGD, low-dose leonurine/MFQ/KN93 groups; MID+OGD, middle-dose leonurine/MFQ/KN93 groups; HIGH+OGD, high-dose leonurine/MFQ/KN93 groups. *P < 0.05 compared with the normal control (0-h OGD) group. **P < 0.01 compared with the normal control (0-h OGD) group. #P < 0.05 compared with the OGD-for-control group. ##P < 0.01 compared with the OGD-for-control group.