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. Author manuscript; available in PMC: 2019 Jul 6.
Published in final edited form as: Circ Res. 2018 Jul 6;123(2):138–158. doi: 10.1161/CIRCRESAHA.118.313251

Figure 4. Examples of paracrine/endocrine actions of intravenously delivered cells.

Figure 4

(A) Intravenously injected cells trapped in the lungs produce TSG-6, which has anti-inflammatory actions and inhibits myocardial recruitment of Ly6G+ and Ly6C+ immune cells. This is an example of endocrine actions of transplanted cells. (B) Intravenously injected cells home to the spleen and modulate splenic inflammatory cells by secreting paracrine factors; this reduces immune cells recruitment in the myocardium.