DNA Replication |
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TOP2A |
Topoisomerase II Alpha, DNA topoisomerase |
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MCM2 |
Minichromosome Maintenance Complex Component 2, involved in replication initiation |
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POLE |
DNA Polymerase Epsilon, Contributes to DNA repair and replication |
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WRN |
Werner Syndrome RecQ Like Helicase, DEAH 5' to 3' DNA with 3' to 5' exonuclease activity |
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PRIM2 |
Primase Subunit 2, DNA directed RNA polymerase that generates lagging |
RNA Processing |
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GTF2H2 |
General Transcription Factor IIH Subunit 2, member of RNA pol II transcription initiation factor IIH complex |
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SRRM1 |
Serine and Arginine Repetitive Matrix 1, Part of pre- and post-splicing multiprotein mRNP complexes |
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XAB2 |
XPA Binding Protein 2, participates in mRNA splicing and nucleotide excision repair |
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NOLC1 |
Nucleolar and Coiled-Body Phosphoprotein, heavily modified regulator of RNA pol I |
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SRSF5 |
Serine Arginine Rich Splicing Factor 5, spliceosome component with an RRM and RS domains |
Transcription, DNA-templated |
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POLR1C |
RNA Pol I subunit C, component of RNA Pol I and III complexes |
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HSPA8 |
Heat Shock Protein Family A Member 8, constitutively expressed member of HSP70 family |
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NCL |
Nucleolin, binds histone H1 to decondense DNA |
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POLR1A |
RNA pol I subunit A, catalytic and largest subunit or RNA Pol I complex |
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POLR2E |
RNA Pol II subunit E, subunit shared between RNA Pol I, II, and III |
Ribonucleoprotein Complex Biogenesis |
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PES1 |
pescadillo, member of PeBoW complex and contributes to ribosome biogenesis, binds BRCA1 |
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BOP1 |
Block of Proliferation 1, participates in rRNA processing and is a member of PeBoW complex |
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NPM1 |
Nucleophosmin, multi-functional nucleolar phosphoprotein |
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DDX21 |
DEAD-Box Helicase 21, facilitates processing or RNA Pol I and II transcripts |
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FBL |
Fibrillarin, rRNA and protein methyltransferase |