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. 2018 Jul 2;7:e35676. doi: 10.7554/eLife.35676

Figure 3. Comparison of single neuronal activity in the striatum and the cerebellar nucleus during the self-timed saccade task.

(A) A representative neuron in the caudate nucleus showing a ramp-up of activity during the delay period. Trials are sorted by saccade latency, and the rasters and corresponding spike density are shown for saccades in contralateral direction. Green, blue, and orange traces indicate data for short, medium, and long mandatory intervals, respectively. (B) A representative neuron in the cerebellar dentate nucleus. Data are shown for saccades in ipsilateral direction. (C) Time courses of the population activity for neurons in the caudate nucleus. Traces are the means of spike densities for individual neurons and are aligned on the cue onset (vertical line). Continuous and dashed traces indicate data for saccades in contralateral and ipsilateral directions, respectively. The filled and open triangles with horizontal bars indicate the mean ± SD of average saccade latency for contralateral and ipsilateral directions in each session, respectively. (D) Time courses of the population activity for neurons in the dentate nucleus. The population data in both structures aligned with saccade initiation are shown in Figure 3—figure supplement 1.

Figure 3—source data 1. Data for Figure 3.
elife-35676-fig3-data1.zip (1.7MB, zip)
DOI: 10.7554/eLife.35676.009
Figure 3—source data 2. Data for Figure 3—figure supplement 1.
elife-35676-fig3-data2.zip (172.2KB, zip)
DOI: 10.7554/eLife.35676.010
Figure 3—source data 3. Data for Figure 3—figure supplement 2.
elife-35676-fig3-data3.zip (113.4KB, zip)
DOI: 10.7554/eLife.35676.011
Figure 3—source data 4. Data for Figure 3—figure supplement 3.
elife-35676-fig3-data4.zip (275.3KB, zip)
DOI: 10.7554/eLife.35676.012

Figure 3.

Figure 3—figure supplement 1. Time courses of the population activity aligned with saccade initiation.

Figure 3—figure supplement 1.

(A) Neurons in the caudate nucleus. Data were aligned with self-timed saccades and were shifted in time to place the end of traces at the mean saccade latencies (vertical lines). The triangles with horizontal bars indicate the mean ± SD of average cue onset time in individual recording sessions. (B) Neurons in the dentate nucleus.
Figure 3—figure supplement 2. Matrix of inter-neuronal correlation.

Figure 3—figure supplement 2.

(A) Neurons in the caudate nucleus. Correlation of the time course of neuronal activity during the delay period in the self-timing task (medium delay condition, preferred direction) was computed for each pair of striatal neurons. Colors represent r2 values. (B) Neurons in the dentate nucleus. Note that the proportion of neuron pairs showing a strong correlation (r2 >0.7) in the dentate nucleus was greater than that in the caudate nucleus (χ2 test, p=2.1E-50), indicating that cerebellar neurons were more stereotyped than striatal neurons.
Figure 3—figure supplement 3. Neuronal activity during the standard memory-guided saccade task and the visually-guided saccade task.

Figure 3—figure supplement 3.

(A) Event sequence in the two tasks. In the standard memory-guided saccade task, monkeys made a saccade to the location of previously presented visual cue in response to the fixation point offset that occurred random 700–2500 ms following the cue onset. In the visually-guided saccade task, the animals made an immediate saccade toward a visible target within 400 ms. (B) Population activity for neurons in the striatum and the cerebellar dentate nucleus during the two saccade tasks. Note that neurons in neither structure showed a ramping activity during the delay period in the standard memory-guided saccade task likely because of the uncertainty about timing of the fixation point offset. In contrast, neurons in both structures often exhibited preparatory activity for visually-guided saccades because the fixation interval was always 800 ms in this task as shown in A. Contra, contralateral; Ipsi, ipsirateral; Mem, standard memory-guided saccade task; Vis, visually-guided saccade task.