Table 2.
Michaelis-Menten parameters for depletion and formation of pesticides in mammals and mixed gender southern toad (Anaxyrus terrestris) liver microsomes, intrinsic clearance rates, and extrapolation of Vmaxin vitro to Vmaxin vivo (values are average ± standard error, ND = not determined).
| Compound | Depletion/Formation | Species | Vmax(pmol min−1 mg−1) | KM (μM) | CLint(mL min−1 kg−1) | Vmax (in vivo) (mg h−1 kg−1)0.75 | Reference |
|---|---|---|---|---|---|---|---|
| ATZ | Depletion | Sprague-Dawley rats | 720 | 27.5 | Adams et al. (1990) | ||
| Fischer rats | 1160 | 27.8 | Adams et al. (1990) | ||||
| Toads | 834 ± 210 | 77 ± 52 | 3.04 | 2.3 | This study | ||
| DIA | Formation | Rats | 1459 ± 266 | 50.4 ± 7.4 | Hanioka et al. (1999b) | ||
| Guinea pigs | 413 ± 31 | 28.4 ± 1.7 | Hanioka et al. (1999b) | ||||
| Mouse | 805 ± 50 | 29.5 ± 1.9 | Hanioka et al. (1999b) | ||||
| Humans | 220.8 ± 8.7 | 440.6 ± 40.2 | Joo et al. (2010) | ||||
| Toads | 124 ± 32 | 36 ± 37 | 1.86 | 0.46 | This study | ||
| DEA | Formation | Rats | 135 ± 27 | 44.5 ± 4.9 | Hanioka et al. (1999b) | ||
| Guinea pigs | 109 ± 10 | 16.2 ± 1.7 | Hanioka et al. (1999b) | ||||
| Mouse | 277 ± 23 | 52.5 ± 4.4 | Hanioka et al. (1999b) | ||||
| Humans | 224.5 ± 6.7 | 79.7 ± 9.5 | Joo et al. (2010) | ||||
| Toads | 112 ± 31 | 17 ± 26 | 0.97 | 0.47 | This study | ||
| TDN | Depletion | Rats | 2860 ± 100 | 2.17 ± 1.6 | Barton et al. (2006) | ||
| Rats (male) | 7452 ± 493 | 47 ± 8 | 245 | Crowell et al. (2010) | |||
| Mouse (male) | 2824 ± 261 | 45 ± 11 | 155 | Crowell et al. (2010) | |||
| Toads | 639 ± 71 | 5 ± 4 | 38.31 | 2.38 | This study | ||
| TDL A | Formation | Rats (male)a | 5703 ± 149 | 61 ± 4 | 142 | Crowell et al. (2010) | |
| Rats (female)a | 344 ± 15 | 78 ± 8 | 7 | Crowell et al. (2010) | |||
| Toads | 281 ± 192 | 147 ± 201 | 0.54 | 1.29 | This study | ||
| TDL B | Formation | Rats (male)a | 5703 ± 149 | 61 ± 4 | 142 | Crowell et al. (2010) | |
| Rats (female)a | 344 ± 15 | 78 ± 8 | 7 | Crowell et al. (2010) | |||
| Mouse (male)a | 1052 ± 38 | 13 ± 2 | 196 | Crowell et al. (2010) | |||
| Mouse (female)a | 1341 ± 52 | 6 ± 1 | 531 | Crowell et al. (2010) | |||
| Toads | 1712 ± 2441 | 239 ± 566 | 2.02 | 5 | This study | ||
| FIP | Depletion | Toads | ND | ND | ND | ND | This study |
| F. Sulfone | Formation | Rats | 390.4 | 19.9 | Tang et al. (2004) | ||
| Human | 107.4 | 27.2 | Tang et al. (2004) | ||||
| Toads | 150 ± 27 | 29 ± 23 | 1.47 | 1.11 | This study |
a
Triadimenol is not divided into its chiral forms.