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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Cancer Res. 2018 May 16;78(14):3865–3876. doi: 10.1158/0008-5472.CAN-18-0056

Figure 4.

Figure 4

Effects of Fluphenazine, Trifluoperazine, and collagen in a mouse model of mammary tumor and bone metastasis. Of note, FP = Fluphenazine, and TFP = Trifluoperazine. The single asterisk indicates p < 0.05. (A&B) Suppression of tumor growth at the mammary pad by Fluphenazine. (C&D) Suppression of tumor growth at the mammary pad by Trifluoperazine. (E) Reconstructed 3D μCT images of the distal femur for the placebo, Fluphenazine-treated, and Trifluoperazine-treated samples. (F) Trabecular thickness and bone volume. (G) Femur stiffness in four-point bending mechanical test. (H&I) Suppression of reduction in bone stiffness by co-injection of collagen into the tibia. (J) Scattered distribution of 4T1.2 tumor cells (highlighted in red) in the tibial bone cavity and smaller average tumor cluster size by co-injection of collagen.