Oncoprint plot showing the deletion landscape of interferon genes, defensin genes, CDKN2A and PTEN in 109 metastatic melanoma patients. Patients were divided into 3 groups including non-responder (N = 72), responder (N = 27) and long-term survival (N = 10), according the response outcomes to ipilimumab. HDI, homozygous deletion of type-I interferons; HDD, homozygous deletion of defensin.