Skip to main content
. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Cancer Res. 2018 Jun 29;78(14):3877–3887. doi: 10.1158/0008-5472.CAN-17-2892

Figure 2.

Figure 2

CypA−/− mice demonstrate decreased lactalbumin (panel A) expression and attenuation of Jak2 (panel B) and Stat5 (panel C) activation during pregnancy and lactation. Paraffin-embedded sections of inguinal mammary glands were immunohistochemically labelled for milk proteins with the designated antibodies at indicated times. Given the heterogeneity of IHC labeling in terms of intensity and positivity, quantitation was performed using Allred scoring. Differences in IHC labeling with anti-whey acidic protein or anti-beta casein between CypA +/+ and −/− tissues were not statistically significant For all studies a minimum of 3 mice were quantitated for each stain, at each time point; * p < 0.05; ** p < 0.01; **** p < 0.001. Selected intervals include: 14 wk virgin (Wk14), pregnancy day 15 (P15), lactation day 2 (L2), and involution day 2 (I2). Corresponding micrographs can be found in Supplemental Figure 2.