Table 3.
Partial correlations between the primary serum and urine biomarkers and Cartilage T2, cartilage WORMS scores, and Meniscus WORMS scores (adjusted for age, gender, BMI, diabetes status, KL grade on both knee sides) with p values and 95% confidence intervals (CI).
| Parameter | sHA | sCOMP | sMMP3 | uCTXII | ||||
|---|---|---|---|---|---|---|---|---|
| Corr. | p value (95% CI) |
Corr. | p value (95% CI) |
Corr. | p value (95% CI) |
Corr. | p value (95% CI) |
|
| Cartilage T2 | ||||||||
| Ave | 0.23 |
0.01 (0.06 0.41) |
0.14 | 0.08 (−0.03 0.31) |
0.23 |
0.006 (0.06 0.41) |
0.13 | 0.14 (−0.04 0.30) |
| LFC | 0.32 |
0.001 (0.16 0.50) |
0.18 |
0.03 (0.01 0.35) |
0.18 |
0.03 (0.01 0.35) |
0.04 | 0.69 (−0.13 0.21) |
| LT | 0.20 |
0.01 (0.03 0.37) |
0.17 |
0.04 (0.00 0.34) |
0.23 |
0.01 (0.06 0.41) |
0.16 | 0.06 (−0.01 0.33) |
| MFC | 0.16 | 0.07 (−0.01 0.33) |
0.01 | 0.86 (−0.16 0.18) |
0.12 | 0.15 (−0.05 0.29) |
0.09 | 0.27 (−0.08 0.26) |
| MT | 0.09 | 0.30 (−0.08 0.26) |
0.06 | 0.47 (−0.11 0.23) |
0.15 | 0.07 (−0.02 0.32) |
−0.01 | 0.89 (−0.18–0.16) |
| PAT | 0.13 | 0.13 (−0.04 0.30) |
0.02 | 0.81 (−0.15 0.19) |
0.13 | 0.15 (−0.04 0.30) |
0.19 |
0.04 (0.02 0.36) |
|
| ||||||||
| Cartilage WORMS | ||||||||
| SUM | 0.07 | 0.41 (−0.10 0.24) |
−0.04 | 0.61 (−0.21 0.13) |
−0.01 | 0.87 (−0.18 0.16) |
0.09 | 0.27 (−0.08 0.26) |
| MAX | 0.12 | 0.14 (−0.05 0.29) |
0.01 | 0.86 (−0.16 0.18) |
−0.02 | 0.80 (−0.19 0.15) |
0.07 | 0.41 (−0.10 0.24) |
| LFC | 0.05 | 0.51 (−0.12 0.22) |
0.06 | 0.46 (−0.11 0.23) |
−0.05 | 0.50 (−0.22 0.12) |
0.14 | 0.11 (−0.03 0.31) |
| LT | 0.13 | 0.11 (−0.04 0.30) |
0.07 | 0.44 (−0.10 0.24) |
−0.01 | 0.93 (−0.18 0.16) |
0.13 | 0.12 (−0.04 0.30) |
| MFC | 0.06 | 0.49 (−0.11 0.23) |
0.01 | 0.96 (−0.16 0.18) |
0.03 | 0.69 (−0.14 0.20) |
0.03 | 0.65 (−0.14 0.20) |
| MT | −0.02 | 0.77 (−0.19 0.15) |
−0.08 | 0.35 (−0.25 0.09) |
0.07 | 0.36 (−0.10 0.24) |
−0.09 | 0.27 (0.26 0.08) |
| PAT | 0.01 | 0.88 (−0.16 0.18) |
−0.08 | 0.33 (−0.25 0.09) |
−0.07 | 0.40 (−0.24 0.10) |
0.08 | 0.36 (−0.25 0.09) |
| TRO | 0.05 | 0.54 (−0.12 0.22) |
0.01 | 0.87 (−0.16 0.18) |
−0.10 | 0.25 (−0.27 0.07) |
0.13 | 0.16 (−0.04 0.30) |
|
| ||||||||
| Meniscus WORMS | ||||||||
| SUM | 0.12 | 0.16 (−0.05 0.29) |
−0.11 | 0.21 (−0.28 0.06) |
0.15 | 0.07 (−0.02 0.32) |
−0.09 | 0.28 (−0.26 0.08) |
| MAX | 0.17 |
0.05 (0.00 0.34) |
−0.13 | 0.13 (−0.30 0.04) |
0.19 |
0.02 (0.02 0.36) |
−0.12 | 0.19 (−0.29 0.05) |
| medial anterior | −0.11 | 0.20 (−0.28 0.06) |
−0.10 | 0.24 (−0.27 0.07) |
−0.11 | 0.20 (−0.28 0.06) |
−0.09 | 0.26 (−0.26 0.08) |
| medial body | 0.19 |
0.02 (0.02 0.36) |
−0.03 | 0.69 (−0.20 0.14) |
0.21 |
0.01 (0.04 0.38) |
−0.09 | 0.33 (−0.26 0.08) |
| medial posterior | 0.09 | 0.28 (−0.08 0.26) |
−0.07 | 0.38 (−0.24 0.10) |
0.07 | 0.39 (−0.10 0.24) |
−0.07 | 0.38 (−0.24 0.10) |
| lateral anterior | −0.05 | 0.57 (−0.22 0.12) |
0.02 | 0.75 (−0.15 0.19) |
0.18 |
0.04 (0.01 0.35) |
−0.06 | 0.50 (−0.23 0.11) |
| lateral body | 0.13 | 0.13 (−0.04 0.30) |
−0.10 | 0.22 (−0.27 0.07) |
0.19 |
0.02 (0.02 0.36) |
0.02 | 0.85 (−0.15 0.19) |
| lateral posterior | 0.02 | 0.74 (−0.15 0.19) |
−0.08 | 0.35 (−0.25 0.09) |
−0.06 | 0.44 (−0.23 0.11) |
−0.02 | 0.81 (−0.19 0.15) |
Abbreviations: Corr. (partial correlation), LFC (lateral femoral condyle), LT (lateral tibia), MFC (medial femoral condyle) MT (medial tibia), PAT (patella), TRO (Trochlea), Ave (average T2 in all compartments) SUM (Summation of WORMS scores across all regions), MAX (Maximum WORMS scores in any region).