Table 3.

Multivariable associations of serum ln hs-CRP with risk of total knee replacement for osteoarthritis

	ln hs-CRP, mg/l HR (95% CI)	P for trend
	White Women
Model 1a	1.16 (1.03–1.30)	0.02
Model 2b	0.91 (0.80–1.04)	0.16
Model 3c	0.93 (0.81–1.07)	0.31
Model 4d	0.94 (0.82–1.09)	0.42
	African American Women
Model 1a	1.39 (1.05–1.85)	0.02
Model 2b	1.12 (0.82–1.51)	0.48
Model 3c	1.14 (0.83–1.58)	0.41
Model 4d	1.21 (0.85–1.72)	0.29
	Hispanic Women
Model 1a	1.25 (0.78–1.99)	0.35
Model 2b	0.93 (0.55–1.56)	0.78
Model 3c	0.69 (0.37–1.26)	0.22
Model 4d	0.66 (0.33–1.31)	0.23

CI, confidence interval; HR, hazard ratio.

^aAdjusted for age.

^bAdjusted for model 2 + body mass index.

^cAdjusted for model 3 + education, pack-years of smoking, alcohol consumption, and physical activity.

^dAdjusted for model 4 + chronic diseases (coronary heart disease, cancer, diabetes, and COPD), hormone therapy use, and non-steroidal anti-inflammatory drug use.