Table 1.
Vehicle (n = 7) | TA-1887 (n = 8) | |
---|---|---|
Urine volume (ml/24 h) | 52 ± 1 | 89 ± 4* |
Urinary glucose excretion (mg/day) | 3 ± 1 | 1933 ± 339* |
Blood pressure (mmHg) | 150 ± 3 | 147 ± 2 |
Body weight (g) | 483 ± 7 | 456 ± 13 |
Kidney weight (g) | 2.2 ± 0.2 | 3.0 ± 0.2* |
plasma BUN (mg/dl) | 45 ± 3 | 55 ± 6 |
Plasma creatinine (mg/dl) | 0.9 ± 0.1 | 0.8 ± 0.1 |
Creatinine clearance (ml/min) | 3.0 ± 0.5 | 2.1 ± 0.2 |
Urinary albumin excretion (mg/day) | 151 ± 4 | 159 ± 5 |
All data are mean ± SEM.
P < 0.05 vs. vehicle.