Table 2.
Demographic and Disease Characteristics of Cohorts identified by Combinations of Codes
| RESOLVE | Septic Shock OR Severe Sepsis codes | Septic Shock AND Severe Sepsis codes only | Angus AND Martin strategies only | All 4 Strategies | |
|---|---|---|---|---|---|
|
| |||||
| n=477 | n=3,598 | n=80 | n=3,510 | n=1,949 | |
| Male sex, n (%) | 28 (54.1%) | 1,939 (53.9%) | 43 (53.8%) | 1,933 (55.1%) | 1,048 (53.9%) |
| Age in years, n (%) | |||||
| 0 to < 1 | 151 (31.7%) | 1,245 (34.6%) | 75 (93.8%) | 1,541 (43.9%) | 387 (19.9%) |
| 1 to < 5 | 149 (31.2%) | 622 (17.3%) | * | 615 (17.5%) | 394 (20.2%) |
| 5 to < 10 | 101 (21.2%) | 449 (12.5%) | * | 366 (10.4%) | 318 (16.3%) |
| 10 to < 18 | 76 (15.9%) | 1,282 (35.6%) | * | 988 (28.1%) | 850 (43.6%) |
| Race | |||||
| White | 314 (65.8%) | 1,504 (42.3%) | 32 (41.0%) | 1,461 (42.3%) | 838 (42.9%) |
| Hispanic | 95 (19.9%) | 637 (17.9%) | * | 589 (17.1%) | 383 (19.7%) |
| African-American | 28 (5.9%) | 885 (24.9%) | 23 (29.4%) | 894 (25.9%) | 440 (22.6%) |
| Asian or Pacific Islander | 13 (2.7%) | 118 (3.3%) | 0 | 115 (3.3%) | 59 (3.0%) |
| Other or Missing Race | 27 (5.7%) | 454 (12.6%) | 13 (16.6%) | 451 (12.8%) | 229 (11.7%) |
| Disease Severity | |||||
| Number of organ failures | |||||
| 1 | 859 (23.9%) | 38 (47.5%) | 1,403 (40.0%) | 353 (18.1%) | |
| 2 | 1,118 (31.1%) | 26 (32.5%) | 1,002 (28.6%) | 590 (30.3%) | |
| 3 | 826 (23.0%) | 12 (15.0%) | 326 (9.3%) | 545 (28.0%) | |
| 4 | 428 (11.9%) | * | 92 (2.6%) | 308 (15.8%) | |
| 5 | 180 (5.0%) | 0 | * | 137 (7.0%) | |
| Number of organ failures, median | 2 | 2 | 1 | 3 | |
| Cardiovascular Failure, n (%) | 2,688 (74.7%) | 80 (100%) | 167 (4.8%) | 1,949 (100%) | |
| Hematologic Failure, n (%) | 928 (25.8%) | * | 1,188 (33.9%) | 568 (29.14%) | |
| Hepatic-Metabolic Failure, n (%) | 1,993 (55.4%) | 31 (38.8%) | 1,635 (46.6%) | 1,177 (60.4%) | |
| Renal Failure, n (%) | 755 (21.0%) | 19 (23.8%) | 394 (11.2%) | 368 (18.9%) | |
| Respiratory Failure, n (%) | 1,721 (47.8%) | * | 1,1173 (33.4%) | 1,004 (51.5%) | |
| Neurologic Failure, n (%) | 208 (5.8%) | * | 246 (7.0%) | 115 (5.9%) | |
| Site of infection | |||||
| Bacteremia | 151 (31.7%) | 3,005 (83.5%) | * | 3,239 (92.3%) | 1,934 (99%) |
| Respiratory | 1,336 (50.6%) | 1,247 (34.7%) | * | 1,028 (29.3%) | 735 (37.7%) |
| Intra-abdominal | 530 (20.1%) | 528 (14.7%) | 0 | 421 (12.0%) | 324 (16.6%) |
| Urinary Tract/GU | 268 (10.2%) | 425 (11.8%) | * | 557 (15.9%) | 235 (12.1%) |
| Other | 479 (18.1%) | 1,183 (32.8%) | * | 1,780 (50.7%) | 657 (33.7%) |
| Mortality | |||||
| 14 day mortality | 67 (14.1%) | 417 (11.6%) | 24 (30.0%) | 87 (2.5%) | 213 (10.9%) |
| 28 day mortality | 82 (17.3%) | 560 (15.6%) | 30 (37.5%) | 140 (4.0%) | 276 (14.2%) |
| In-hospital mortality | 82 (17.3%) | 763 (21.2%) | 39 (48.8%) | 261 (7.4%) | 352 (18.1%) |
| One year mortality | 867 (24.1%) | 41 (51.3%) | 406 (11.6%) | 1.0%) | |
*
Indicates number <11, which cannot be presented due to the terms of our data use agreement (to protect patient confidentiality).