Table 2.
Baseline characteristics stratified by MRE and TE concordance in the Mayo Clinic NAFLD Cohort
| Characteristics | All (n=75) | TE and MRE concordant (n=41) | TE and MRE discordant (n=34) | p-value* |
|---|---|---|---|---|
| Demographics | ||||
| Age (years) | 47.68 (11.51) | 47.73 (11.39) | 47.62 (11.8) | 0.966 |
| Female, n (%) | 50 (66.7) | 29 (53.6) | 21 (61.7) | 0.412 |
| Clinical | ||||
| BMI (kg/m2) | 41.7 (7.1) | 40.0 (7.0) | 43.5 (6.8) | 0.031 |
| Biological data | ||||
| AST (U/L) | 59.8 (90.6) | 72.3 (119.9) | 45.5 (33.4) | 0.328 |
| ALT (U/L) | 79.0 (103.80) | 89.5 (133.0) | 67.8 (61.9) | 0.556 |
| Alk P (U/L) | 89.2 (27.1) | 95.0 (33.4) | 83.1 (17.3) | 0.243 |
| Albumin (g/dL) | 4.20 (0.40) | 4.19 (0.44) | 4.21 (0.35) | 0.915 |
| Platelet count (109/L) | 220.26 (71.8) | 217.4 (83.1) | 224.1 (54.1) | 0.709 |
| INR | 1.26 (0.90) | 1.45 (1.1) | 0.99 (0.1) | 0.272 |
| Histology | ||||
| Fibrosis | 0.016 | |||
| 0 | 33 (44.0) | 21 (51.2) | 12 (35.3) | |
| 1 | 22 (29.3) | 11 (26.8) | 11 (32.4) | |
| 2 | 9 (12.0) | 2 (4.9) | 7 (20.6) | |
| 3 | 3 (4.0) | 0 (0.0) | 3 (8.8) | |
| 4 | 8 (10.7) | 7 (17.1) | 1 (2.9) | |
| Imaging data | ||||
| MRE kPa | 3.17 (1.54) | 3.3 (2.0) | 3.0 (0.7) | 0.029 |
| Liver stiffness (kPa) | ||||
| Median, median (IQR) | 6.40 (4.32) | 5.80 (3.27) | 8.72 (3.76) | <0.001 |
| IQR, median (IQR) | 0.97 (0.84) | 0.92 (0.81) | 1.07 (1.42) | 0.153 |
| IQR/M, median (IQR) | 0.13 (0.11) | 0.14 (0.09) | 0.11 (0.13) | 0.466 |
| Unreliable liver stiffness*, n (%) | 14 (18.7) | 0 (0.0) | 14 (41.2) | <0.001 |
*
P-value determined by comparing characteristics of concordant and discordant individuals for TE and MRE using an independent samples t-test or Wilcoxon Rank Sum Test. Chi-square test or Fisher’s Exact Test, where appropriate, was used to compare categorical variables. Bold indicates significant P-values <0.05.