TABLE 1.
Decay properties, production methods, chelators, and theranostic pair for potential PET-radiometals. The gamma spectrum for each radiometal listed below is provided as Supporting Information (Figure S1)
| Radionuclide | t1/2 | Average β+Energy/ Iβ+ (%) | Principle γ Emissions / Iγ (%) | Optimal Production Method | Typical Chelators | Theranostic Partner Isotope |
|---|---|---|---|---|---|---|
| 89Zr | 78.4 h | 396 keV/ 23% | 909 keV/ 99% | Cyclotron | DFO HOPO DOTA |
- |
| 64Cu | 12.7 h | 278 keV/ 18% | - | Cyclotron | NOTA DOTA TETA SAR family | 67Cu |
| 86Y | 14.7 h | 660 keV/ 32% | 1076 keV/83% 628 keV/33% 1153 keV/31% 777 keV/22% 1921 keV/21% 1854 keV/17% |
Cyclotron | DOTA DTPA |
90Y |
| 52Mn | 5.6d | 242 keV/ 29% | 1434 keV/ 100% 935 keV/95% 744 keV/90% |
Cyclotron | DOTA | - |
| 55Co | 17.5 h | 570 keV/76% | 931 keV/75% 1409 keV/17% |
Cyclotron | DOTA HBED TETA NOTA |
58mCo |
| 152Tb | 17.5 h | 1140 keV/20% | - | Proton-induced spallation | DOTA | 161Tb |
| 90Nb | 14.6 h | 620 keV/51% | 1129 keV/93% 2319 keV/82% 141 keV/67% 2186 keV/18% |
High energy cyclotron | DFOA | - |
| 66Ga | 9.3 h | 1750 keV/57% | 1039 keV/37% 2752 keV/23% 4295 keV/4% |
Cyclotron | DOTA NOTA |
71Ga |
| 72As | 26.0 h | 1170 keV/88% | 834 keV/81% 630 keV/8% |
Cyclotron | Trithiol / lipoic acid | 77As |
| 69Ge | 39.1 h | 490 keV/24% | 1107 keV/36% 574 keV/13% 872 keV/12% |
Cyclotron | Metal oxide nanoparticles | - |