Table 1.
Inter-event time, concentration and duration of spontaneous adenosine transients in the pre-frontal cortex, thalamus, and CA1 region of the hippocampus under control conditions and with A1 antagonist, DPCPX (100 nM)
| Brain Region | Inter-event Time (s) | Concentration (nM) | Duration (s) | |||||
|---|---|---|---|---|---|---|---|---|
| Median | Mean | 100nM DPCPX | Median | Mean | 100nM DPCPX | Mean | 100nM DPCPX | |
| Prefrontal cortex | 20 | 50 (±5) |
53 (±4) |
90 | 160 (±10) |
160 (±10) |
3.4 (±0.1) |
3.6 (±0.1) |
| Thalamus | 133 | 280 (±40) |
210 (±30) |
90 | 110 (±10) |
210 (±20)**** |
7.4 (±0.4) |
6.2 (±0.4)* |
| Hippocampus (CA1) | 30 | 79 (±7) |
58 (±7)** |
140 | 240 (±20) |
310 (±10)**** |
4.9 (±0.2) |
5.4 (±0.2) |
Errors are SEM
*
Significantly different distributions than control for that region (Kolmogorov-Smirnov tests for inter-event times and concentrations; unpaired t-test for duration)