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. 2018 Jul 17;8:10780. doi: 10.1038/s41598-018-29236-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time-dependent stimulation of collagen synthesis and deposition in fibroblasts incubated with and without TGF-β1. (A) Soluble collagen in the supernatant. (B) Pepsin-solubilized collagen fraction associated to cell monolayer. (C) Insoluble collagen deposited into the matrix. Collagen fractions were determined from cells incubated for 1 to 4 days in the absence (white bars) or presence of 5 ng/ml TGF-β1 (black bars) as described under Materials and Methods. Values are represented as μg collagen per million of cells (mean ± SEM, n = 6; *P < 0.05 or **P < 0.01vs one day in the absence of TGF-β1, and ^#P < 0.05 vs the corresponding time value in the absence of TGF-β1).