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. 2018 Jul 17;8:10785. doi: 10.1038/s41598-018-29107-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of DMLs across the human genome. Modified manhattan plot of CpG dinucleotides examined in this study (dots) reveals differentially methylated loci (DMLs) to be distributed across the entire genome. Positively and negatively correlated DMLs are displayed with the −log10 of the aLIS P-value. While all loci examined alternate between black and gray dots, to indicate each chromosome, significant DMLs are displayed outside of the dashed lines (aLIS P-value < 0.2).