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. 2018 Jul 17;8:10814. doi: 10.1038/s41598-018-29144-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The gene expression level of SPHK1 positively correlated with those of lymphangiogenesis-related or lymphatic metastasis-related substrates in biliary tract cancer. Pearson correlations were calculated between gene expression level of SPHK1 and those of ACER1, DEGS1, ORMDL1, ABCC1, S1PR4, IL6, VEGFC, CCR7, CCL21 and PDPN in biliary tract cancer in TCGA cohort (36 samples of cancer tissue in cholangiocarcinoma cohort). All tests were two-sided, and P values < 0.05 were considered statistically significant.