Table 2.

Association of pre-diagnostic inflammatory score (A) and the first PC (B) with breast cancer case/control.

	Full Breast Cancer population										TtD ≤ 6 years*		TtD > 6 years*
	Model 1		Model 1 + Behaviours		Model 1 + SEP		Model 1 + Hormonal		Fully adjusted model		Fully adjusted model		Fully adjusted model
	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value
(A) Inflammatory score
All	−0.96 (0.99)	0.333	−1.28 (1.01)	0.208	−1.27 (1.02)	0.215	−1.35(1.05)	0.201	−1.72(1.09)	0.118	−2.88(1.32)	0.032	−0.06(1.43)	0.970
EPIC-Italy	−1.12 (1.43)	0.436	−2.03 (1.47)	0.170	−1.45 (1.45)	0.318	−1.33(1.57)	0.400	−2.36(1.63)	0.151	−3.52(1.81)	0.057	1.03(2.67)	0.701
NSHDS	−0.64 (1.37)	0.640	−0.25 (1.54)	0.871	−0.86 (1.47)	0.558	−1.72(1.57)	0.278	−1.75 (1.88)	0.356	−3.58 (2.70)	0.196	−2.56 (1.88)	0.181
(B) Principal component 1
All	−0.56 (0.53)	0.297	−0.74 (0.54)	0.175	−0.64 (0.55)	0.241	−0.87(0.55)	0.166	−1.00(0.57)	0.083	−1.55(0.70)	0.029	−0.09(0.75)	0.906
EPIC-Italy	−0.75 (0.77)	0.335	−1.25 (0.81)	0.123	−0.87 (0.79)	0.273	−0.83(0.84)	0.322	−1.30(0.88)	0.147	−1.90(1.04)	0.074	0.83(1.42)	0.564
NSHDS	−0.17 (0.71)	0.810	−0.004(0.77)	0.996	−0.23 (0.76)	0.760	−0.93 (0.81)	0.253	−0.85 (0.92)	0.361	−1.45 (1.22)	0.242	−1.29 (1.02)	0.214

Pooled cohorts (n = 167), EPIC-Italy (n = 94) and NSHDS (n = 73).

Model 1 is adjusted for age and cohort in the overall BC population; for age and center in EPIC-Italy and age in NSHDS.

β coefficient regression estimates inflammatory score’s (A) or PC1’s (B) difference in cases compared to controls.

*Additional analyses stratified by time from blood collection to cases’ diagnosis included for ‘less than 6 years’ strata 49 BC cancer cases: 32 in EPIC-Italy and 17 in NSHDS; for ‘higher than 6 years’ strata 41 BC cancer cases: 17 in EPIC-Italy and 24 in NSHDS.