Table 3.
Association of pre-diagnostic inflammatory score (A) and the first PC (B) with B-cell non-Hodgkin lymphoma case/control.
| Full Lymphoma population | TtD ≤ 6 years* | TtD > 6 years* | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 1 + Behaviours | Model 1 + SEP | Fully adjusted model | Fully adjusted model | Fully adjusted model | |||||||
| β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | β (SE) | P-value | |
| (A) Inflammatory score | ||||||||||||
| All | −1.28 (0.51) | 0.012 | −1.19 (0.51) | 0.021 | −1.21 (0.51) | 0.019 | −1.11 (0.52) | 0.032 | −1.27 (0.65) | 0.051 | −1.06 (0.66) | 0.108 |
| EPIC-Italy | −0.89 (0.87) | 0.310 | −0.93 (0.89) | 0.299 | −0.96 (0.88) | 0.277 | −1.02 (0.90) | 0.258 | −1.87 (1.08) | 0.087 | 0.05 (1.20) | 0.965 |
| NSHDS | −1.48 (0.63) | 0.019 | −1.31 (0.64) | 0.040 | −1.36 (0.63) | 0.031 | −1.19 (0.64) | 0.062 | −0.71 (0.82) | 0.389 | −1.61 (0.79) | 0.043 |
| (B) Principal component 1 | ||||||||||||
| All | −0.77 (0.26) | 0.004 | −0.71 (0.26) | 0.007 | −0.71 (0.26) | 0.007 | −0.65 (0.26) | 0.013 | −0.76 (0.32) | 0.018 | −0.60 (0.33) | 0.073 |
| EPIC-Italy | −0.59 (0.40) | 0.138 | −0.66 (0.40) | 0.101 | −0.62 (0.40) | 0.126 | −0.70 (0.40) | 0.083 | −1.14 (0.47) | 0.017 | −0.13 (0.54) | 0.816 |
| NSHDS | −0.85 (0.34) | 0.012 | −0.73 (0.34) | 0.032 | −0.76 (0.34) | 0.024 | −0.64 (0.34) | 0.059 | −0.48 (0.43) | 0.263 | −0.82 (0.42) | 0.053 |
Pooled cohorts (n = 496), EPIC-Italy (n = 167) and NSHDS (n = 329)
Model 1 is adjusted for age, gender, phase and cohort in the overall all B-cell NHL population; for age, gender, phase and center in EPIC-Italy and age, gender, phase in NSHDS. β coefficient regression estimates inflammatory score’s (A) or PC1’s (B) difference in cases compared to controls.
*Additional analyses stratified by time from blood collection to cases’ diagnosis included for ‘less than 6 years’ strata 129 B-cell NHL cancer cases: 49 in EPIC-Italy and 80 in NSHDS; for ‘higher than 6 years’ strata 119 B-cell NHL cancer cases: 35 in EPIC-Italy and 84 in NSHDS.