Table 5.
List of kinases identified as intermediate-value targets and their druggability features.
| Gene | Kp13 Locus ID^ | Product | Druggability features | Subcellular localization |
|---|---|---|---|---|
| anmK | 05161 | Anhydro-N-acetylmuramic acid kinase | CP, PB overexpressed, PathoKp: 100%, Microbiome: 12.8% | Cytoplasmic Membrane |
| argB | 00555 | Acetylglutamate kinase | CP, Essential, PathoKp: 100%, Microbiome: 8.4% | Cytoplasmic |
| bglK | 03813 | Beta-glucoside kinase | CP, PathoKp: 97.4%, Microbiome: 1.3% | Cytoplasmic |
| folK | 01855 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase | CP, Essential, PathoKp: 100%, Microbiome: 33.2% | Cytoplasmic |
| iolC | 01316 | 5-dehydro-2-deoxygluconokinase | CP, PB overexpressed, PathoKp: 100%, Microbiome: 4.9% | Cytoplasmic |
| lysC | 00360 | Lysine-sensitive aspartokinase 3 | CP, PB overexpressed, PathoKp: 100%, Microbiome: 8% | Cytoplasmic |
| mak | 02078 | Fructokinase | CP, PB overexpressed, PathoKp: 100%, Microbiome: 7.1% | Cytoplasmic |
| selD | 05414 | Selenide, water dikinase | CP, PB overexpressed, PathoKp: 100%, Microbiome: 21.2% | Cytoplasmic |
| thiL | 02043 | Thiamine-monophosphate kinase | CP, Essential, PathoKp: 100%, Microbiome: 11.5% | Unknown |
| thrB | 01992 | Homoserine kinase | CP, Essential, PathoKp: 100%, Microbiome: 8% | Cytoplasmic |
^The K. pneumoniae Kp13 locus suffix ‘KP13_’ is omitted. CP, choke-point; PB, polymyxin B; pathoKp. % conservation in 38 pathogenic K. pneumoniae; Microbiome, % conservation in 226 gut genomes.