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Measurement of glomerular filtration rate in experimental groups.
| Vehicle | HCTZ | Probenecid (250 mg/kg) | Probenecid + HCTZ | |
|---|---|---|---|---|
| Creatinine Clearance (ml/min) | 0.45 ± 0.02 | 0.53 ± 0.061 | 0.72 ± 0.07∗ | 0.63 ± 0.08# |
∗Vehicle (0.45 ± 0.02, n = 5) vs. 10 day Probenecid (0.72 ± 0.0723, n = 4); p = 0.004. #Vehicle (0.45 ± 0.02, n = 5) vs. Probenecid + HCTZ (0.63 ± 0.07, n = 4); p = 0.03.
