Table 2.
Systemic acid base and electrolyte homeostasis.
| Arterial pH | pCO2 (mmHg) | HCO3- (mM/L) | Serum Na+ (mEq/L) | Serum K+ (mEq/L) | Serum Ca2+ (mM/L)] | |
|---|---|---|---|---|---|---|
| Vehicle | 7.32 ± 0.01 | 61.84 ± 1.78 | 31.86 ± 0.39 | 135.20 ± 0.73 | 4.98 ± 0.24 | 1.29 ± 0.03 |
| Probenecid (250 mg/kg) | 7.36 ± 0.02 | 53.34 ± 1.12∗ | 30.32 ± 0.58 | 136.60 ± 0.24 | 5.18 ± 0.10 | 1.16 ± 0.01% |
| HCTZ | 7.34 ± 0.02 | 59.12 ± 1.70 | 32.22 ± 1.28 | 136.20 ± 0.73 | 4.74 ± 0.16 | 1.24 ± 0.02 |
| Probenecid + HCTZ | 7.36 ± 0.02 | 55.44 ± 1.68# | 31.66 ± 1.10 | 136.60 ± 0.81 | 4.24 ± 0.15+,∧ | 1.19 ± 0.05 |
∗Vehicle pCO2 (61.84 ± 1.78, n = 5) vs. probenecid pCO2 (53.34 ± 1.12, n = 5); p = 0.003. #Vehicle pCO2 (61.84 ± 1.78, n = 5) vs. probenecid + HCTZ pCO2 (55.44 ± 1.68, n = 5); p = 0.03. +Vehicle K+ (4.98 ± 0.24, n = 5) vs. probenecid + HCTZ K+ (4.24 ± 0.15, n = 5); p = 0.03. ∧Probenecid K+ (5.18 ± 0.10, n = 5) and probenecid + HCTZ (4.24 ± 0.15, n = 5); p = 0.0007. %Vehicle Ca2+ (1.27 ± 0.03, n = 5) vs. probenecid (1.16 ± 0.01, n = 5); p = 0.001.