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. 2018 Jul 11;9:724. doi: 10.3389/fphar.2018.00724

FIGURE 4.

FIGURE 4

The effect of the i.t. administration of an IDO2 inhibitor (1-MT) and a KMO inhibitor (UPF 648) at a dose of 20 μg/5 μl on mechanical (von Frey test; A,C) and thermal (cold plate test; B,D) hypersensitivity in rats on days 2 and 7 after the CCI. Both KMO inhibitors significantly reduced hypersensitivity. The results are presented as the means ± SEM (10–16 rats per group). Inter-group differences were analyzed via one-way ANOVA followed by a Bonferroni’s test for multiple comparisons. ∗∗∗p < 0.001 indicates a difference compared to the naïve group; #p < 0.05, ##p < 0.01, and ###p < 0.001 indicate differences compared to the V-treated CCI-exposed group. N, naïve group; V, vehicle (DMSO-treated CCI exposed group); 1-D-MT, IDO2 inhibitor; UPF 648, KMO inhibitor.