Table 3.
Univariate and multivariable logistic regression models for HF.
| Unadjusted OR | P-value | Adjusted for Model 1 OR | P-value | Adjusted for Model 2 OR | P-value | |
|---|---|---|---|---|---|---|
| In all subjects | ||||||
| Log IL-34 per SD | 1.549 (1.335–1.798) | <0.001 | 1.551 (1.327–1.814) | <0.001 | 1.501 (1.249–1.803) | <0.001 |
| IL-34 tertiles | 1.712 (1.438–2.039) | <0.001 | 1.732 (1.431–2.076) | <0.001 | 1.521 (1.219–1.898) | <0.001 |
| 1st tertile | 1 (ref) | 1 (ref) | 1 (ref) | |||
| 2nd tertile | 2.366 (1.662–3.367) | <0.001 | 2.259 (1.562–3.267) | <0.001 | 1.768 (1.139–2.744) | 0.011 |
| 3rd tertile | 2.987 (2.097–4.253) | <0.001 | 2.925 (2.085–4.390) | <0.001 | 2.324 (1.491–3.621) | <0.001 |
| In CAD patients | ||||||
| Log IL-34 per SD | 1.429 (1.198–1.705) | <0.001 | 1.393 (1.163–1.669) | <0.001 | 1.391 (1.137–1.702) | <0.001 |
| IL-34 tertiles | 1.563 (1.269–1.925) | 0.001 | 1.528 (1.233–1.894) | <0.001 | 1.417 (1.121–1.791) | <0.001 |
| 1st tertile | 1 (ref) | 1 (ref) | 1 (ref) | |||
| 2nd tertile | 2.274 (1.495–3.457) | <0.001 | 2.155 (1.405–3.305) | <0.001 | 1.675 (1.043–2.690) | 0.011 |
| 3rd tertile | 2.475 (1.637–3.742) | <0.001 | 2.360 (1.542–3.611) | <0.001 | 2.020 (1.266–3.224) | <0.001 |
IL-34 is analyzed as a log transformed continuous variable, an ordinal variable divided according to tertiles of IL-34, and a categorical variable using the lowest tertile as reference. Model 1: adjusted for age, gender, and body mass index. Model 2: adjusted for age, gender, body mass index, smoke, history of hypertension, history of DM, history of dyslipidemia, log WBC, log hsCRP, log HbA1c, hemoglobin, log albumin, LDL-C, eGFR and medication. As a continuous variable, OR is shown as per 1 SD (standard deviation). CAD, coronary artery disease; DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; HF, heart failure; hsCRP, high sensitivity C reactive protein; IL-34, interleukin 34; LDL, low-density lipoprotein; OR, odds ration; WBC, white blood cell.