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. 2018 Jul 11;12:277. doi: 10.3389/fnhum.2018.00277

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Copyright © 2018 At least a portion of this work is authored by Gang Chen on behalf of the U.S. Government and, as regards Dr. Chen and the US government, is not subject to copyright protection in the United States. Foreign and other copyrights may apply

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of the time effect. (A) For the L1 group, the hippocampal activation decreased from 30-min to 1-day, and 30-min to 1-month. The EC/PRC showed increased activation from 30-min to 1-month. (B,C) For the L6 group, the activation of the parahippocampal cortex (PHC) and parahippocampal place area (PPA) significantly increased when 30-min was compared with 1-day and 1-month intervals. The brain activation in the red frame represents the contrast of 30-min vs. 1-day, and that in the blue frame represents the contrast of 30-min vs. 1-month. The left is on the left side for each brain slice. The color bar represents the contrast between recent vs. remote intervals (e.g., 30-min vs. 1-day). The signal changes of the left hippocampus, PHC and PPA in the contrast of 30-min vs. 1-day (i.e., red frame) are plotted for each condition.