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. 2018 Jul 11;9:907. doi: 10.3389/fphys.2018.00907

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Copyright © 2018 Rouhimoghadam, Safarian, Carroll, Sheibani and Bidkhori.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the expression level of intended DEGs using qPCR. Bak1, PUMA, ERK3 and MAP2K2 genes were overexpressed in tamoxifen-treated MCF-7 cancer cells, while the expression level of MAPK3 was not significantly changed. On the contrary, ER (ESR1), GREB and RARA were depressed under tamoxifen induction. Each value is the mean ± SD of three separate experiments. The statistical significant differences are indicated with ^∗ for p < 0.05.