Figure 2.

Altered PML expression levels reciprocally interacting with HBsAg levels correlate with distinct pathology and phenotypes of lipid metabolism and HBsAg-induced HCCs in mice. Representative images of gross livers and H&E histology with higher magnification of double immunostaining for PML (brown color in the nuclei) and HBsAg (red color in the cytoplasm) from HBsAg^tg/0 mice with or without one or two copies of PML knockdown are compared after HCC development. Note that PML^−/-HBsAg^tg/0, PML^+/+HBsAg^tg/0 and PML^+/-HBsAg^tg/0 mice display early-onset adipose-like solid-form HCC, late-onset fatless angiogenic trabecular-type HCC, and mixed adipose-angiogenic features of HCC, respectively. Squares represent in-situ zoomed regions.