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An example of putting the ROIs in a co-registrated enhanced T1 weighted image (a, d, g), intracellular volume fraction (icvf: b, e, h) and orientation dispersion index (ODI: c, f, I) maps, respectively. a, b, c: in tumour parenchyma, ROI was designed to be as large as possible to cover the tumour parenchyma; d, e, f: ROI was within 1 cm from the outer enhancing tumour margin in peritumoural area; g, h, i: ROI was placed in contralateral normal-appearing white matter.
