Fig. 3.

Upper images (a, b, c, d, e) show a 51-year-old male with low grade gliomas (e, pathologically confirmed gemistocytic astrocytoma, haematoxylin-Eosin (HE) × 10) which mainly is located in left temporal lobe and left basal ganglia region. Lower images (f, g, h, i, j) demonstrate a 61-year-old male with high grade gliomas (j, pathologically proved as glioblastoma, haematoxylin-Eosin (HE) × 10) in the left frontal lobe. Both tumours had obvious necrosis on T2 weighted images (a, f) and the tumour parenchyma showed vivid enhancement (b, g); however, the higher-grade glioma showed slightly higher ODI value (d, i) and, further, the icvf map (c, h) showed that high grade glioma with higher icvf value in tumour parenchyma.