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. 2018 May 25;22(8):3955–3964. doi: 10.1111/jcmm.13675

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© 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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ABHD11‐AS1 is co‐immunoprecipitated with cyclin D1. Overexpression of ABHD11‐AS1 increased the expression of cyclin D1, CDK1, CDK2, CDK4, Bcl‐xl and VEGFA and decreased the expression of p16; conversely, the opposite results were observed in HEC‐1B cells transfected with si‐ABHD11‐AS1 (A). RNA pull‐down assays showed that lncRNA ABHD11‐AS1 is co‐immunoprecipitated with cyclin D1 (B). Western blotting of the xenograft tumour tissues from the nude mouse model showed that overexpression of ABHD11‐AS1 increased the expression of cyclin D1, CDK1, CDK2, CDK4, Bcl‐xl and VEGFA and decreased the expression of p16 (C)