Fig. 7. (A) Confocal laser scanning microscopy imaging of miR-21 in (a) MCF-7 cells using the CHA–HCR system, (b) MCF-7 cells using the CHA system, (c) inhibitor-treated MCF-7 cells using the CHA–HCR system and (d) Hela cells using the CHA–HCR system. (B) The statistical histogram analysis of the FRET signals collected from a large number of the corresponding living cells under a series of Z-stack projections. (C) FRET efficiency of the CHA–HCR-imaging system derived from 50 of MCF-7 living cells.
