Table 2. Substrate scope of enantioselective intramolecular S_N2′ reaction ^a .

Entry	1 and 2(R)	Conditions	Yield b (%)	ee c (%)
1 d	b: 4-MeOC6H4–	–60 °C, 12 h	98	79
2 d	c: 4-MeC6H4–	–60 °C, 12 h	96	90
3	d: 4-ClC6H4–	–50 °C, 48 h	90	91
4	e: 3-MeOC6H4–	–50 °C, 12 h	90	90
5	f: 3-MeC6H4–	–60 °C, 48 h	97	91
6	g: 3-ClC6H4–	–40 °C, 36 h	88	88
7	h: 3-CF3C6H4–	–40 °C, 48 h	86	89
8	i: 2-MeOC6H4–	–40 °C, 12 h	90	60
9	j: 2-MeC6H4–	rt, 24 h	Trace	—
10	k: 2-FC6H4–	–20 °C, 12 h	87	87
11 d	l: 2-Naphthyl	–60 °C, 12 h	85	86
12	m: Ph–C C–	–40 °C, 48 h	55	60
13 d	n: Thiophen-3-yl	–60 °C, 8 h	95	91

^aUnless otherwise noted, all reactions were carried out using 0.01 mmol of (R)-3d (10 mol%), 0.1 mmol of (E)-1, and MS 4A (50 mg) in chloroform (1.0 mL).

^bIsolated yield.

^cee was determined by chiral stationary phase HPLC analysis.

^d5 mol% of (R)-3d was used.