Fig. 6.

Intracerebral LPS induces systemic inflammation serum α₁-acid glycoprotein (AGP) concentrations, as determined by ELISA. Significantly increased AGP levels were detected in LPS-treated animals, but not in HMGB1-treated animals (LPS vs. pre-op, p = 0.003; LPS vs. saline, p = 0.0129). Data are expressed as median ± IQR. p values were calculated using a Kruskal-Wallis test corrected for multiple comparisons using the Dunn test (n = 8–12 rats/group). * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001. See legend to Fig. 1 for abbreviations.