Figure 1.

Statistical model selection. We generated a range of synthetic data sets with (a) three diffusive states and (b) defocus-dependent localization root mean-square errors, and estimated the number of states using (c) variational maximal evidence (VB), and (d) cross-validation using variational pseudo-Bayes factors using 10% of the data in the validation set (PBF 10%). For details, see Methods. To see this figure in color, go online.