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. 2018 May 31;27(6):867–878. doi: 10.1177/0963689718759472

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 5. — Summary of neurotrophins and their application in spinal cord injury (SCI). The potential roles for key neurotrophins during the 3 phases of olfactory ensheathing cell (OEC) transplantation therapy for SCI (cell preparation, cell administration, and continuous support). OEC preparation may be enhanced using neurotrophin 3 (NT-3) and nerve growth factor (NGF). Cell administration may be supported using NT-3, NGF, glial-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF). Ongoing support to the injury/transplantation site may be achieved through the use of NT-3, fibroblast growth factor 2 (FGF2), epidermal growth factor (EGF), GDNF, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF).