Table 1.
Baseline characteristics of participants in the AASK and BioMe studies
| Variable | AASK | BioMe |
|---|---|---|
| N | 588 | 678 |
| Mean age, year, (SD) | 54.2 (10.5) | 60.3 (13.1) |
| Men, n (%) | 351 (59.7) | 472 (69.6) |
| Mean body mass index, kg/m2, (SD)a | 31.1 (6.7) | 31.2 (8.2) |
| GFRa,b mL/min per 1.73m2 | 47.4 (13.4) | 58.8 (13.9) |
| Urine PCR, mg/g, median (first, third quartile)c | 72 (27, 308) | – |
| Urine ACR, mg/g, median (first, third quartile)a | – | 13 (4.0, 84) |
| CHD, n (%)a | 294 (50.0) | 47 (6.9) |
| Mean SBP (SD), mm Hga | 150.1 (24.6) | 134.7 (23.0) |
| Mean DBP (SD), mm Hga | 95.6 (15) | 76.8 (12.5) |
| Hypertension, n (%)a | 588 (100.0) | 512 (75.5) |
| Diabetes, n (%)a | 0 (0) | 278 (41.0) |
| % European ancestrya | 0.2 (0.1) | 0.2 (0.2) |
| APOL1 risk allele, n (%) | ||
| 0 copies | 194 (33.0) | 246 (36.3) |
| 1 copy | 255 (43.4) | 226 (33.3) |
| 2 copies | 139 (23.6) | 206 (30.4) |
| G1 (rs73885319) | ||
| AA | 302 (51.4) | 370 (54.6) |
| AG | 224 (38.1) | 221 (32.6) |
| GG | 59 (10.0) | 87 (12.8) |
| G2 (rs7178513) | ||
| Wild type | 419 (71.3) | 473 (69.8) |
| One deletion | 147 (25.0) | 167 (24.6) |
| Two deletion | 21 (3.6) | 38 (5.6) |
a
BioMe sample size: body mass index (484), eGFR (647), urinary albumin-to-creatine ratio (177), SBP (665), DBP (671), CHD (677), hypertension (677), and diabetes (677); % European ancestry (478).
b
AASK used measured GFR and BioMe used eGFR calculated from serum creatinine using the CKD Epidemiology Collaboration equation.
c
AASK sample size: proteinuria (586).