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. 2018 May 18;29(7):1939–1947. doi: 10.1681/ASN.2017101064

Table 2.

Study population characteristics, by tertile of 6-bromotryptophan

Variable AASK BioMe
Tertile 1 Tertile 2 Tertile 3 Tertile 1 Tertile 2 Tertile 3
Mean age, year, (SD) 54.4 (10.2) 54.3 (10.2) 54.0 (11.2) 60.24 (12.3) 60.08 (13.0) 60.67 (13.9)
Men, n (%) 107 (54.6) 116 (59.2) 128 (65.3) 148 (65.5) 160 (70.8) 164 (72.6)
Mean body mass index, kg/m2 (SD)a 30.8 (7.6) 31.2 (6.1) 31.3 (6.5) 30.4 (8.4) 32.24 (8.5) 31.88 (7.2)
GFRa,b mL/min per 1.73m2 43.0 (13.6) 47.6 (13.8) 51.5 (11.5) 56.03 (16.2) 59.57 (12.1) 60.72 (12.6)
Urine PCR, mg/g, median (25th, 75th percentile)c 121 (37, 512) 65 (28, 311) 54 (22, 196)
Urine ACR, mg/g, median (25th, 75th percentile)a 20 (3, 147) 12 (5, 41) 8.5 (3, 31)
CHD, n (%)a 103 (52.6) 89 (45.4) 102 (52) 14 (6.2) 14 (6.2) 19 (8.4)
Mean SBP (SD), mm Hga 148.6 (22.5) 150.3 (24.1) 151.4 (27.0) 131.5 (20.5) 137.6 (25.0) 135.0 (22.9)
Mean DBP (SD), mm Hga 94.7 (14.1) 94.8 (15.3) 97.3 (15.4) 74.66 (11.2) 77.55 (12.6) 78.29 (13.3)
Hypertension, n (%)a 196 (100) 196 (100) 196 (100) 159 (70.4) 176 (78.2) 177 (78.3)
Diabetes, n (%)a 0 (0) 0 (0) 0 (0) 118 (52.2) 80 (35.6) 80 (35.4)
% European ancestrya 0.16 (0.12) 0.17 (0.14) 0.17 (0.14) 0.18 (0.15) 0.18 (0.16) 0.19 (0.18)
APOL1 risk allele, n (%)
 0 copies 53 (27) 65 (33.2) 76 (38.8) 73 (32.3) 85 (37.6) 88 (38.9)
 1 copy 78 (39.8) 90 (45.9) 87 (44.4) 73 (32.3) 74 (32.7) 79 (35.0)
 2 copies 65 (33.2) 41 (20.9) 33 (16.8) 80 (35.4) 67 (29.6) 59 (26.1)
G1 (rs73885319)
 AA 87 (44.4) 100 (51.3) 115 (59.3) 116 (51.3) 124 (54.9) 130 (57.5)
 AG 82 (41.8) 76 (39.0) 66 (34.0) 72 (31.9) 83 (36.7) 66 (29.2)
 GG 27 (13.8) 19 (9.7) 13 (6.7) 38 (16.8) 19 (8.4) 30 (13.3)
G2 (rs7178513)
 Wild type 11 (5.6) 4 (2.0) 6 (3.1) 158 (69.9) 151 (66.8) 164 (72.6)
 One deletion 50 (25.6) 49 (25.0) 48 (24.5) 51 (22.6) 63 (27.9) 53 (23.5)
 Two deletion 134 (68.7) 143 (73.0) 142 (72.4) 17 (7.5) 12 (5.3) 9 (4)
a

BioMe sample size: body mass index (545), eGFR (658), urinary albumin-to-creatine ratio (177), SBP (673), DBP (677), CHD (677), hypertension (677), diabetes (677); % European ancestry (478).

b

AASK used measured GFR, BioMe used eGFR.

c

AASK sample size for proteinuria: 586.