Table 2.
Variable | AASK | BioMe | ||||
---|---|---|---|---|---|---|
Tertile 1 | Tertile 2 | Tertile 3 | Tertile 1 | Tertile 2 | Tertile 3 | |
Mean age, year, (SD) | 54.4 (10.2) | 54.3 (10.2) | 54.0 (11.2) | 60.24 (12.3) | 60.08 (13.0) | 60.67 (13.9) |
Men, n (%) | 107 (54.6) | 116 (59.2) | 128 (65.3) | 148 (65.5) | 160 (70.8) | 164 (72.6) |
Mean body mass index, kg/m2 (SD)a | 30.8 (7.6) | 31.2 (6.1) | 31.3 (6.5) | 30.4 (8.4) | 32.24 (8.5) | 31.88 (7.2) |
GFRa,b mL/min per 1.73m2 | 43.0 (13.6) | 47.6 (13.8) | 51.5 (11.5) | 56.03 (16.2) | 59.57 (12.1) | 60.72 (12.6) |
Urine PCR, mg/g, median (25th, 75th percentile)c | 121 (37, 512) | 65 (28, 311) | 54 (22, 196) | – | – | – |
Urine ACR, mg/g, median (25th, 75th percentile)a | – | – | – | 20 (3, 147) | 12 (5, 41) | 8.5 (3, 31) |
CHD, n (%)a | 103 (52.6) | 89 (45.4) | 102 (52) | 14 (6.2) | 14 (6.2) | 19 (8.4) |
Mean SBP (SD), mm Hga | 148.6 (22.5) | 150.3 (24.1) | 151.4 (27.0) | 131.5 (20.5) | 137.6 (25.0) | 135.0 (22.9) |
Mean DBP (SD), mm Hga | 94.7 (14.1) | 94.8 (15.3) | 97.3 (15.4) | 74.66 (11.2) | 77.55 (12.6) | 78.29 (13.3) |
Hypertension, n (%)a | 196 (100) | 196 (100) | 196 (100) | 159 (70.4) | 176 (78.2) | 177 (78.3) |
Diabetes, n (%)a | 0 (0) | 0 (0) | 0 (0) | 118 (52.2) | 80 (35.6) | 80 (35.4) |
% European ancestrya | 0.16 (0.12) | 0.17 (0.14) | 0.17 (0.14) | 0.18 (0.15) | 0.18 (0.16) | 0.19 (0.18) |
APOL1 risk allele, n (%) | ||||||
0 copies | 53 (27) | 65 (33.2) | 76 (38.8) | 73 (32.3) | 85 (37.6) | 88 (38.9) |
1 copy | 78 (39.8) | 90 (45.9) | 87 (44.4) | 73 (32.3) | 74 (32.7) | 79 (35.0) |
2 copies | 65 (33.2) | 41 (20.9) | 33 (16.8) | 80 (35.4) | 67 (29.6) | 59 (26.1) |
G1 (rs73885319) | ||||||
AA | 87 (44.4) | 100 (51.3) | 115 (59.3) | 116 (51.3) | 124 (54.9) | 130 (57.5) |
AG | 82 (41.8) | 76 (39.0) | 66 (34.0) | 72 (31.9) | 83 (36.7) | 66 (29.2) |
GG | 27 (13.8) | 19 (9.7) | 13 (6.7) | 38 (16.8) | 19 (8.4) | 30 (13.3) |
G2 (rs7178513) | ||||||
Wild type | 11 (5.6) | 4 (2.0) | 6 (3.1) | 158 (69.9) | 151 (66.8) | 164 (72.6) |
One deletion | 50 (25.6) | 49 (25.0) | 48 (24.5) | 51 (22.6) | 63 (27.9) | 53 (23.5) |
Two deletion | 134 (68.7) | 143 (73.0) | 142 (72.4) | 17 (7.5) | 12 (5.3) | 9 (4) |
BioMe sample size: body mass index (545), eGFR (658), urinary albumin-to-creatine ratio (177), SBP (673), DBP (677), CHD (677), hypertension (677), diabetes (677); % European ancestry (478).
AASK used measured GFR, BioMe used eGFR.
AASK sample size for proteinuria: 586.