Figure 5.

Treatment with anti-properdin (anti-P) mAb prevented renal and extrarenal pathology in FH^R/R mice. (A) Periodic acid–Schiff staining of kidney sections of control mAb-treated FH^R/R mice showed thrombotic microangiopathy pathology in the glomeruli, whereas anti-P mAb-treated mice exhibited normal glomerular histology. (B) Prominent fibrin staining was present in the glomeruli of control mAb-treated mice, but fibrin staining was not detected in anti-P mAb-treated mice. (C) C3 staining of a granular pattern was detected in the glomeruli of both control and anti-P mAb-treated mice. (D) Hematoxylin and eosin staining of liver sections illustrating that large-vessel thrombi (yellow arrows) were found in the organs of control mAb-treated FH^R/R mice but not in anti-P mAb-treated FH^R/R mice. Scale bars, 25 μm in A–C; 100 μm in D.