Table 3.

Anti-properdin mAb treatment ameliorated renal pathology in FH^R/R mice

Treatment Group	Expanded Matrix and Endothelial Swelling, %	Microthrombi, %	Large Vein Thrombi, %	Glomerular Sclerosis, %	Arteriolar Hyalinosis, %
FHR/R + control mAb	66.7	100	33.3	0.7	100
FHR/R + anti-P mAb once weekly	6.2	10	0	0	0
FHR/R + anti-P mAb twice weekly	5	0	0	0	0

At least three kidney sections from each mouse were examined for five characteristic thrombotic microangiopathy–related pathologic change in hematoxylin and eosin and periodic acid–Schiff staining. All glomeruli on a given section were scored. FH^R/R + control mAb, n=15; FH^R/R + anti-P mAb once weekly, n=10; FH^R/R + anti-P mAb twice weekly, n=5.