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. 2018 Jun 14;29(7):2000–2013. doi: 10.1681/ASN.2017111185

Figure 3.

Figure 3.

Transethnic meta-analysis and conditional analyses. (A) Manhattan plot for the transethnic meta-analysis. One genome-wide significant single-nucleotide polymorphism (SNP) is identified at 6p21 in the HLA class 2 region (top SNP, rs1063348). There are two SNPs that reach suggestive levels of significance: rs59882675 (P=5.9×10−8) in an intron of betacellulin on chromosome 4q13 and rs2858829 (P=6.8×10−8) in an intergenic region between Family With Sequence Similarity 26 Member F and Dermatan Sulfate Epimerase on chromosome 6q22. (B) Locus zoom on the 6p21 region of the transethnic meta-analysis. The recombination rate across the region is represented as blue lines. The top SNP from this analysis is rs1063348 (6:32627923), with a P value of 9.3×10−23. The lower panel contains genes in this region, with the inclusion of rs1063348 in the 3′ untranslated region of HLA-DQB1. (C) 6p21 conditioned on rs1063348. Transethnic meta-analysis genome-wide association study (GWAS) P values in the 6p21 region conditional on rs1063348 are shown. The top SNP from this analysis is rs28366266 (6:32559753), with a P value of 3.7×10−11. The lower panel shows the location of rs28366266 upstream of HLA-DRB1. (D) 6p21 conditioned on top two significant SNPs. Transethnic meta-analysis GWAS P values in the 6p21 region conditional on both rs1063348 and rs28366266 are shown. The top SNP in this region from this analysis is rs9348883 (6:32358549), with a P value of 9.4×10−7. The lower panel shows the location of rs9348883 within HLA Complex Group 23 and LOC101929163, 3′ of butyrophilin like-2.