Figure 5.

Age of disease onset in genome-wide association study (GWAS) and Nephrotic Syndrome Study Network (NEPTUNE) cohorts as a function of increased burden of rs1063348 and rs28366266 risk alleles. (A) GWAS cohorts. Linear regression of age of onset by summed risk alleles from rs1063348 and rs28366266. Lines and values correspond to linear regression predictions. Note a significant relationship with more risk alleles and lower age of onset. (B) The NEPTUNE cohort. Linear regression of age of onset by summed risk alleles from rs1063348 and rs28366266, stratified by histologic diagnosis. Lines and values correspond to linear regression predictions, with colors corresponding to overall regression (red), regression in patients diagnosed with FSGS (green), regression in patients diagnosed with minimal change disease (MCD; blue), and regression in patients with other proteinuric glomerulopathies (purple). There were not enough patients diagnosed with membranous nephropathy to perform linear regression alone. Note a significant relationship with more risk alleles and lower age of onset.