Table 2.
Significant single-nucleotide polymorphisms, test statistics, and values from the trans-ethnic meta-analysis and conditional analyses
| SNP | Risk Allele | Other Allele | Risk AF | Meta-Analysis across Cohorts, n=3652 (385 Crossethnic Patients; 3267 Crossethnic Controls) | Meta-Analysis, Conditional on rs1063348, n=3652 (385 Crossethnic Patients; 3267 Crossethnic Controls) | Meta-Analysis, Conditional on rs1063348 and rs28366266, n=3652 (385 Crossethnic Patients; 3267 Crossethnic Controls) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR [95% CI] | P Value | Q Test | OR [95% CI] | P Value | Q Test | OR [95% CI] | P Value | Q Test | ||||
| rs1063348 (6:32627923) | Ga | A | 0.60 | 3.33 [2.62 to 4.23] | 9.30E−23 | 0.79 | — | — | — | — | — | — |
| rs28366266 (6:32559753) | Ca | T | 0.17 | 3.03 [2.40 to 3.85] | 4.10E−20 | 0.09 | 2.17 [1.73 to 2.74] | 3.66E−11 | 0.36 | — | — | — |
| rs9348883 (6:32358549) | Ta | A | 0.94 | 2.51 [1.49 to 4.22] | 4.70E−04 | 0.68 | 2.57 [1.53 to 4.31] | 3.40E−04 | 0.81 | 3.5 [2.13 to 5.83] | 9.40E−07 | 0.70 |
Genome-wide association study (GWAS) results for top SNPs of interest: rs1063348, top SNP in meta-analysis across cohorts; rs28366266, top SNP in meta-analysis conditional on rs1063348; and rs9348883, top SNP in meta-analysis conditioned on rs1063348 and rs28366266. For each SNP, we present the GWAS results in the crosspopulation meta-analysis of all individual cohorts taken together (n=3652, including 385 patients and 3267 controls) and the conditional crosspopulation meta-analysis conditioned on rs1063348 alone and then rs1063348 and rs28366266 together. ORs with 95% CIs and P values are reported for each SNP in each analysis. SNP, single-nucleotide polymorphism; AF, allele frequency; OR, odds ratio; 95% CI, 95% confidence interval; —, not tested.
Risk allele.