Table 3.
Summary statistics for the top SNPs from the trans-ethnic and conditional analyses within ancestry specific cohorts
| SNP | African Cohort, n=510 (56 IDF-AFR Patients; 454 1000G-AFR Controls) | European (French) Cohort, n=2132 (132 IDF-EUR Patients; 2000 3 Cités Controls) | Maghrebian Cohort, n=346 (85 IDF-MAG Patients; 261 Moroccan Controls) | European (Replication) Cohort, n=664 (112 ItSpa Patients; 552 1000G-EUR Controls) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR [95% CI]a | P Valueb | Risk AF | OR [95% CI]a | P Valueb | Risk AF | OR [95% CI]a | P Valueb | Risk AF | OR [95% CI]a | P Valueb | Risk AF | |
| rs1063348 (6:32627923) | 3.24 [1.93 to 5.45] | 3.06E−07 | 0.48 | 2.96 [2.04 to 4.29] | 1.17E−08 | 0.61 | 3.62 [1.97 to 6.68] | 3.70E−05 | 0.68 | 4.05 [2.42 to 6.79] | 1.06E−07 | 0.64 |
| rs28366266 (6:32559753) | 3.2 [1.78 to 5.76] | 1.10E−04 | 0.11 | 2.25 [1.59 to 3.2] | 5.64E−06 | 0.17 | 3.53 [1.99 to 6.28] | 1.74E−05 | 0.20 | 4.93 [2.94 to 8.27] | 1.34E−09 | 0.19 |
| rs9348883 (6:32358549) | 5.66 [0.96 to 33.4] | 5.60E−02 | 0.93 | 1.92 [0.82 to 4.59] | 1.30E−01 | 0.95 | 3.95 [0.88 to 17.67] | 6.10E−02 | 0.95 | 2.35 [1.08 to 5.14] | 3.21E−02 | 0.93 |
Genome-wide association study (GWAS) results within ancestry specific cohorts for top SNPs of interest: rs1063348, top SNP in meta-analysis across cohorts; rs28366266, top SNP in meta-analysis conditional on rs1063348; and rs9348883, top SNP in meta-analysis conditioned on rs1063348 and rs28366266. ORs with 95% CIs and P values are reported for each SNP in each analysis. SNP, single-nucleotide polymorphism; IDF-AFR, Ile-de-France African; 1000G-AFR, 1000 Genomes project African; IDF-EUR, Ile-de-France European; IDF-MAG, Ile-de-France Maghrebian; ItSpa, Italian and Spanish; 1000G-EUR, 1000 Genomes project European; OR, odds ratio; 95% CI, 95% confidence interval; AF, allele frequency.
Adjusted SEM by sqrt(λ) from each cohort.
P value adjusted by cohort-specific λ.