Cell metabolic cartoon constructed from the annotation of the “Ca. Nitrotoga fabula” genome. Enzyme complexes of the electron transport chain are labeled with Roman numerals. Table S4 contains further information on the depicted enzymes and pathways. Abbreviations: ACIII, alternative complex III; AnoI/R, acyl-homoserine-lactone synthase/response regulator; CA, carbonic anhydrase; CAT, catalase; CLD, chlorite dismutase; CoA, coenzyme A; CRISPR, clustered regularly interspaced short palindromic repeats; CysH, adenylyl-sulfate reductase; CysND, sulfate adenylyltransferase; HOX, bidirectional group 3d [NiFe] hydrogenase; 2-Hydroxyethyl-ThPP, 2-hydroxyethyl thiamine diphosphate MSC, mechanosensitive channel; NAS, assimilatory nitrite reductase; NirK, nitrite reductase; NXR, nitrite oxidoreductase; RND transporter, resistance-nodulation-cell division transporter; QAC, quaternary ammonium compound; SOD, superoxide dismutase; SIR, assimilatory sulfite reductase; Sor, sulfite:cytochrome c oxidoreductase; TAT, twin-arginine translocation; TCA cycle, tricarboxylic acid cycle; Sec, secretion.